There currently are three hosts of the channel, the most active being Andre Segers who works on and stars in a majority of their videos. The channel is also hosted by Ash Paulsen and Derrick Bitner.
Whilst GameXplain has been uploading videos to YouTube for five years, they have had a website (GameXplain.com) prior and have been making videos since 2003.
The channel currently has many different segments, some on the YouTube channel and some exclusive to their website.
Whenever a new trailer for a video game comes out, GameXplain posts an Analysis Video detailing all the little hints and clues that could allude to bigger things. For example, in a Mario Kart 8 analysis they discovered numerous new track names on a sign before Nintendo officially announced the tracks. They usually only analyze Nintendo games.
Andre, Ash, and Derrick often post discussion videos where they get together and discuss a particular topic. These topics usually include speculation on their part and wishes they would like to see in upcoming games.
GameXplain points out little things in games that they find really cool. These videos usually are very small, lasting only around three minutes.
Know Your Enemy
Derrick explains the history behind various video game enemies
Amazing Super Mario Maker Levels
Andre showcases levels he made in Super Mario Maker. He sometimes showcases levels made by other users.
Missing in Action
GameXplain tracks down video game elements that go missing and explain the history behind them.
GameXplain also has one-off videos that usually include showing off a certain thing in a game, such as all the boss battles in a game. They also review different games and upload guides of different games.